Mark Twain Casino sits at La Grange in the far north-east corner of Missouri, on the Mississippi upriver from Hannibal. It rates 3.6 from around 1,600 Google reviewers.
This is the smallest end of the Missouri casino market and it is worth being plain about that. La Grange is a town of a few hundred people, the floor is 18,000 square feet, and the property exists to serve north-east Missouri and the Illinois and Iowa borders rather than to draw anyone across the state.
What's on the floor
More than 600 slot and video poker machines and 13 table games, plus electronic table games.
Thirteen live tables is more than you would expect at a floor this size — Missouri's licence structure means even the smallest properties carry a real pit. Check the venue's site for the current table schedule before planning around a specific game; with thirteen tables, the spread varies by shift.
The casino is operated by Affinity Gaming, which runs its A-Play loyalty programme across its properties.
Electronic table games fill the gaps when the live pit is closed, which at a property with these hours is a meaningful share of the week.
Dining and the RV park
Three rooms: the Fireside Sports Bar & Grill, Bistro 104 and the Sizzlin' 7s Grill.
The RV park is small and seasonal — eight spaces with level pads, room for a slide-out and full water, sewer and electricity hookups, open 1 March through 31 October on a first-come, first-served basis. Eight spaces is genuinely tiny, so do not build a trip around securing one.
There is no hotel on site.
Tips before you go
You must be 21 to gamble, the minimum age at every Missouri casino.
The casino is not open 24 hours. It runs 10am to 2am Sunday through Thursday, and 10am to 4am on Friday and Saturday. That makes it one of the more restricted schedules in the state — worth knowing if you are driving in from Quincy or Keokuk late.
The Mississippi setting is genuinely pleasant, and the property sits close enough to the Illinois and Iowa lines that a good share of the floor on a weekend has crossed a state border to get there.
La Grange is roughly twenty minutes north of Hannibal, Mark Twain's boyhood town, which is the obvious pairing for a day out. The casino takes its name from the same source.
Nearby alternatives
West across the state, St. Jo Frontier Casino at St. Joseph is the other small northern Missouri floor. South, River City Casino serves south St. Louis County, and Horseshoe St. Louis is the downtown floor with a WSOP poker room.
For the full picture, see all Missouri in-person casinos.
FAQ
What are Mark Twain Casino's hours?
10am to 2am Sunday through Thursday, and 10am to 4am Friday and Saturday. It is not a 24-hour property.
How old do you have to be to gamble at Mark Twain Casino?
You must be 21, the minimum age at every Missouri casino.
What games are available at Mark Twain Casino?
More than 600 slot and video poker machines and 13 table games across an 18,000-square-foot floor, plus electronic table games. Check the venue's site for the current table schedule.
Does Mark Twain Casino have an RV park?
A small seasonal one — eight spaces with full hookups, open 1 March through 31 October, first come first served.
Does Mark Twain Casino have a hotel?
No. Accommodation is in Hannibal or Quincy nearby.
How far is Mark Twain Casino from Hannibal?
About twenty minutes north, at La Grange on the Mississippi.
Rather play from your couch tonight? See our Missouri sweepstakes rankings.
Updated August 2026 · Details verified against Missouri Gaming Commission records and the venue's official site. Hours and offerings change — confirm before you go.
